Chinese Journal of Organic Chemistry >
Application of Cascade Reactions in the Synthesis of Sprio-hetero- cycles Initiated by Intramolecular Cyclization of Alkynols
Received date: 2020-06-23
Revised date: 2020-07-28
Online published: 2020-08-19
Supported by
the National Natural Science Foundation of China(21602207); the Doctoral Research Fund of Zhengzhou University of Light Industry(2014BSJJ009); the Young Backbone Teachers’ Fund of Zhengzhou University of Light Industry(2019XGGJS010)
Due to their unique stereoscopic structure and rich physical and chemical properties, spiro heterocyclic compounds have aroused the continuous attention of researchers on their efficient synthesis methods. The exo-cyclic enol ethers generated in situ by exo-dig cyclization of alkynols under the promotion of transition metals could serve as C2 synthons to react with various "amphiphilic substrates" through cascade reactions mode. These cascade reactions could afford spiro heterocyclic skeletons in highly efficient and direct manners. In this paper, the application progress of cascade reactions in the synthesis of sprio-heterocycles initiated by intramolecular cyclization of alkynols is reviewed, which aims to stimulate the disclosure of more related research work. These work is elaborated according to the different atom numbers of the "amphiphilic substrates" involved in the construction of the spiro framworks. The catalytic system and reaction mechanism are mainly described, the challenges in this field are analyzed, and the future development is also put forward.
Key words： sprio-heterocycles; alkynols; cascade reactions; exo-cyclic enol ether
Shuyan Yu , Lihong Gao , Yizhe Yan , Zhigang Yin , Yongjia Shang . Application of Cascade Reactions in the Synthesis of Sprio-hetero- cycles Initiated by Intramolecular Cyclization of Alkynols[J]. Chinese Journal of Organic Chemistry, 2021 , 41(2) : 582 -593 . DOI: 10.6023/cjoc202006050
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