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Chinese Journal of Organic Chemistry >

2021 , Vol. 41 >Issue 1: 407 - 411

DOI: https://doi.org/10.6023/cjoc202007011

NOTES

Direct Nucleophilic Substitution of Propargyl Alcohols with Enoxysilanes

  • Xinling Li ,
  • Huili Liu ,
  • Shunji Zhang
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  • a Department of Chemistry, Huaibei Normal University, Huaibei, Anhui 235000

Received date: 2020-07-04

  Revised date: 2020-08-06

  Online published: 2020-08-27

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Abstract

A novel and efficient synthesis of γ-alkynyl ketones by the direct nucleophilic substitution of propargyl alcohols with enoxysilanes in the presence of a catalytic amount of p-toluenesulfonic acid monohydrate, has been developed. The reactions can be performed in an undried solvent under an air atmosphere to obtain the desired products in good yields.

Key words： Keywords propargyl alcohol; enoxysilane; nucleophilic substitution; catalyzed; p-toluenesulfonic acid

Cite this article

Xinling Li , Huili Liu , Shunji Zhang . Direct Nucleophilic Substitution of Propargyl Alcohols with Enoxysilanes[J]. Chinese Journal of Organic Chemistry, 2021 , 41(1) : 407 -411 . DOI: 10.6023/cjoc202007011

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