Chinese Journal of Organic Chemistry >
Recent Progress in Catalytic Asymmetric Alkynylation of Imines
Received date: 2020-07-16
Online published: 2020-09-09
Supported by
the Open Project Program of Key Laboratory of Functional Small Organic Molecule, Ministry of Education, Jiangxi Normal University(KLFS-KF-201603); the Foundation of Jiangxi Educational Committee(170223)
Chiral propargyl amines are key intermediates in the asymmetric total synthesis of natural products and bioactive compounds. The asymmetric alkynylation of imine and its analogues can provide a highly efficient and enantioselective synthetic route for these chiral building blocks. In addition, through rational substrate and reaction design, the asymmetric alkynylation of imines can be used as the starting point of a series of cascade reactions to synthesize a variety of novel nitrogen-heterocyclic compounds. Therefore, highly efficient and enantioselective alkynylation of imines and their analogues has attracted the continuous attention of synthetic chemists. According to the types of substrate, the research progress in asymmetric alkynylation of imines and their analogues over the past decade is introduced, which is divided into two parts: asymmetric alkynylation of aldimines and asymmetric alkynylation of ketoimines. The reaction mechanism and their advantages and disadvantages, together their synthetic applications will be briefly introduced, hoping to provide some useful inspiration for expanding the application of this reaction in synthesis.
Shurui Zhou , Kaige Wen , Xingping Zeng . Recent Progress in Catalytic Asymmetric Alkynylation of Imines[J]. Chinese Journal of Organic Chemistry, 2021 , 41(2) : 471 -489 . DOI: 10.6023/cjoc202007043
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