Chinese Journal of Organic Chemistry >
Nucleophilic Etherification of Heteroaryl Alkyl Ethers, Heteroaryl Halides with (Deuterated) Alcohols
Received date: 2020-06-30
Revised date: 2020-08-20
Online published: 2020-10-12
Supported by
the Huxiang Young Talent Program from Hunan Province(2019RS2022)
A KOt-Bu empowered transition-metal free and efficient procedure for the etherification of alkoxy heteroarenes, heteroaryl halides and heteroaryl thioethers with various primary, secondary, tertiary aliphatic alcohols has been developed. The usefulness of our method is highlighted by the derivatization of natural products and bioactive molecules, and the synthesis of deuterated heteroaryl alkyl ethers that are not easy to access via other approaches.
Xia Wang , Yixin Qu , Chengyu Long , Xue-Qiang Wang . Nucleophilic Etherification of Heteroaryl Alkyl Ethers, Heteroaryl Halides with (Deuterated) Alcohols[J]. Chinese Journal of Organic Chemistry, 2021 , 41(2) : 795 -805 . DOI: 10.6023/cjoc202006077
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