Chinese Journal of Organic Chemistry >
Application of Flow Chemistry in Halogenation
Received date: 2020-07-22
Revised date: 2020-09-14
Online published: 2020-10-12
Supported by
National Natural Science Foundation of China(21877087); National Natural Science Foundation of China(21602164); Open Fund of Hubei Key Laboratory of Novel Reactor and Green Chemical Technology (Wuhan Institute of Technology)(K202004)
The halogenation of organic compounds is one of the most important transformations in organic synthesis. However, there are some problems in traditional batch halogenation, such as high exothermicity, poor selectivity and the use of highly toxic and corrosive halogenating agents. Flow chemistry has its unique advantages such as high mixing efficiency, fast heat and mass transfer performance, accurate control over process parameters and enhanced process safety, reduced energy input and so on. According to the classification of halogenation of organic compounds, the main progress of flow chemistry in fluorination, chlorination, bromination and iodization is summarized systematically, and its development trend is prospected.
Key words： flow chemistry; microreactor; continuous flow; halogenation; organic synthesis
Ding Liu , Yuanyuan Zhu , Shuangxi Gu , Fener Chen . Application of Flow Chemistry in Halogenation[J]. Chinese Journal of Organic Chemistry, 2021 , 41(3) : 1002 -1011 . DOI: 10.6023/cjoc202007051
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