Chinese Journal of Organic Chemistry >
Application of Organocatalysis in Asymmetric Construction of Nitrogen-Containing Heterocyclic Compounds
Received date: 2020-08-20
Revised date: 2020-09-22
Online published: 2020-10-12
Supported by
the National Natural Science Foundation of China(Nos. 21576296); the National Natural Science Foundation of China(21776318); the National Natural Science Foundation of China(81703365)
Nitrogen-containing heterocyclic structures are widely encountered in natural products and pharmaceuticals, which demonstrate broad-spectrum biological and pharmacological activities, and have attracted intensive attention from organic chemists and medicinal chemists. As a consequence, developing their green and efficient pathways, especially in asymmetric fashion, has always been a hot research field in the synthetic chemistry. In recent years, a series of organocatalysts based on amino acid such as proline and pyroglutamic acid have been reported, which have been well applied in the asymmetric construction of various nitrogen-containing compounds. This account mainly focuses on the research of asymmetric synthesis of nitrogen-containing heterocyclic compounds in our group, and the possible mechanisms of some typical reactions are thus discussed.
Key words： organocatalysis; asymmetric synthesis; N-heterocycle; proline; pyroglutamic acid
Yu Zheng , Zhenzhen Xie , Kai Chen, , Haoyue Xiang, , Hua Yang, . Application of Organocatalysis in Asymmetric Construction of Nitrogen-Containing Heterocyclic Compounds[J]. Chinese Journal of Organic Chemistry, 2021 , 41(1) : 1 -11 . DOI: 10.6023/cjoc202008037
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