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Chinese Journal of Organic Chemistry >

2020 , Vol. 40 >Issue 12: 4315 - 4321

DOI: https://doi.org/10.6023/cjoc202008031

Synthesis and Biological Activities of Novel Pyrazole Oxime Derivatives Containing Benzotriazolyl Moiety

  • Zhu Yue ,
  • Zheng Dandan ,
  • Miao Heyi ,
  • Qian Cheng ,
  • Dai Hong ,
  • Liang Kai ,
  • Zhou Beibei ,
  • Shi Yujun ,
  • Xun Xiao ,
  • Wang Yang
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  • College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019

Received date: 2020-08-18

  Revised date: 2020-09-27

  Online published: 2020-10-15

Supported by

Project supported by the National Natural Science Foundation of China (Nos. 21372135, 21802075), and the Science and Technology Project Fund of Nantong City (No. MS12019060).

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Abstract

In search of new N-heterocyclic compounds possessing good biological activities, 17 novel pyrazole oxime derivatives were designed and synthesized by introducing benzotriazole moiety into pyrazole oxime skeleton based on fenpyroximate. Their structures were tested by 1H NMR, 13C NMR and elemental analysis. Preliminary bioassay data displayed that 3 compounds showed 70%~100% insecticidal activities towards Tetranychus cinnabarinus at 20 μg/mL. 6 compounds possessed 90%~100% mortality rates towards Aphis medicaginis at 20 μg/mL. Moreover, 16 compounds displayed more than 80% insecticidal activities against Mythimna separata (Walker) at 500 μg/mL.

Key words： benzotriazole; pyrazole oxime; synthesis; biological activity

Cite this article

Zhu Yue , Zheng Dandan , Miao Heyi , Qian Cheng , Dai Hong , Liang Kai , Zhou Beibei , Shi Yujun , Xun Xiao , Wang Yang . Synthesis and Biological Activities of Novel Pyrazole Oxime Derivatives Containing Benzotriazolyl Moiety[J]. Chinese Journal of Organic Chemistry, 2020 , 40(12) : 4315 -4321 . DOI: 10.6023/cjoc202008031

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