Chinese Journal of Organic Chemistry >
Synthesis and Fungicidal Activity of Novel Allyl Benzoate Compounds Containing Triazole
Received date: 2020-06-19
Revised date: 2020-07-20
Online published: 2020-10-22
Supported by
the Natural Science Foundation of Zhejiang Province(LY19C140002); the Research Fund of Department of Education of Zhejiang Province(Y201941832)
In order to find pesticide lead compounds with high fungicidal activity, a series of unreported allyl benzoate compounds containing triazole were designed and synthesized. The structures were confirmed by 1H NMR and HRMS, and the crystal structure of (R,S)-(Z)-1,3-diphenyl-2-(1H-1,2,4-triazol-1-yl)allyl 2,3-dichlorobenzoate (5j) was determined by X-ray single crystal diffraction. The bioassay results showed that (R,S)-(Z)-1,3-diphenyl-2-(1H-1,2,4-triazol-1-yl)allyl benzoate (5a), (R,S)-(Z)-1,3-diphenyl-2-(1H-1,2,4-triazol-1-yl)allyl 2-fluorobenzoate (5g) and (R,S)-(Z)-1,3-diphenyl-2-(1H-1,2,4-triazol-1- yl)allyl 3-methylbenzoate (5n) exhibited good control efficacy against Sclerotinia sclerotiorummore than 70% at 50 mg/L.
Wei Yu , Han Wang , Li-Jing Min , Xue-Wen Hua , Xing-Hai Liu . Synthesis and Fungicidal Activity of Novel Allyl Benzoate Compounds Containing Triazole[J]. Chinese Journal of Organic Chemistry, 2021 , 41(2) : 826 -832 . DOI: 10.6023/cjoc202006037
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