Chinese Journal of Organic Chemistry >
Recent Advance on the Synthesis of 3,3'-Bisindolylmethane Derivatives under Transition-Metal-Free Catalytic Conditions
Received date: 2020-08-05
Revised date: 2020-10-13
Online published: 2020-10-22
Supported by
the Start-up Grant of Nanjing Tech University(38037037); the Synergetic Innovation Center for Advanced Materials Fellowship and Postgraduate Research & Practice Innovation Program of Jiangsu Province(KYCX20_1031)
3,3'-Bisindolylmethanes (3,3'-BIMs) compounds are important indole alkyloads and their units are widely found in various natural products, functional materials and synthetic pharmaceutical compounds. Due to diverse biological activities and functionalities, for instance, antioxidant, anti-inflammatory, antiangiogenic, anti-bacterial and anti-cancer etc., the construction of 3,3'-BIMs is raised considerable concerns. Conventional methods especially focused on symmetrical 3,3'-BIMs were the condensition of indoles with carbonyl compounds via Friedel-Crafts pathway in the presence of Brønsted acids or Lewis acids. However, the utilization of transtion metals led the residue into the products and environmental contamination. The recent advance on the synthesis of 3,3'-BIMs since 2010, mainly concerned on the approaches and corresponding me- chanism to prepare symmetrical and unsymmetrical 3,3'-BIMs under transition-metal-free conditions is summarized and dis- cussed, aiming to provide important theoretical evidence and techinical support for further biological evaluations on desired compounds.
Zhenguo Zhang , Xiaoxiao Liu , Xinlong Zong , Yalin Yuan , Shuanglei Liu , Ting Zhang , Zishang Wu , Jingying Yang , Zhenhua Jia . Recent Advance on the Synthesis of 3,3'-Bisindolylmethane Derivatives under Transition-Metal-Free Catalytic Conditions[J]. Chinese Journal of Organic Chemistry, 2021 , 41(1) : 52 -64 . DOI: 10.6023/cjoc202008003
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