Chinese Journal of Organic Chemistry >
Efficient Copper-Catalyzed Domino Synthesis of Phosphonated Isoquinolin-1(2H)-ones Using Cyanomethylphosphonates as Building Blocks
Received date: 2020-08-25
Revised date: 2020-10-18
Online published: 2020-10-22
Supported by
the Natural Science Foundation of Shandong Province(ZR2016JL012); the Scientific Research Foundation of Qingdao University of Science and Technology.()
An efficient and convenient copper-catalyzed cascade synthesis of C-4 phosphonated isoquinolin-1(2 H)-ones has been initially proposed. This is the first example for the construction of phosphine-containing heterocycles through copper-catalyzed Ullmann-type coupling reactions using cyanomethylphosphonates as the building blocks, and it will broaden the strategies of organophosphorus synthesis in the field of organic and pharmaceutical chemistry.
Suyan Zhao , Xueqin Gong , Ziyu Gan , Qiuli Yan , Xueliang Liu , Daoshan Yang . Efficient Copper-Catalyzed Domino Synthesis of Phosphonated Isoquinolin-1(2H)-ones Using Cyanomethylphosphonates as Building Blocks[J]. Chinese Journal of Organic Chemistry, 2021 , 41(1) : 258 -266 . DOI: 10.6023/cjoc202008045
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