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Chinese Journal of Organic Chemistry >

2021 , Vol. 41 >Issue 3: 1246 - 1250

DOI: https://doi.org/10.6023/cjoc202008002

NOTES

A New Prenylated Isoflavone from the Stems and Leaves of Trigonostemon howii

  • Yanhui Fu ,
  • Yutong Xie ,
  • Qingwei Ma ,
  • Bo Jiang ,
  • Lan Xie ,
  • Zehua Qiao ,
  • Yanping Liu
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  • a Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Hainan Normal University, Haikou 571127
    b Engineering Research Center for Industrialization of Southern Medicinal Plants Resources of Hainan province,Hainan Normal University, Haikou 571127
    c Key Laboratory of Southern Medicinal Plants Resources of Haikou City, Hainan Normal University, Haikou 571127
    d State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009
* Corresponding author. E-mail:

Received date: 2020-08-04

  Revised date: 2020-09-13

  Online published: 2020-11-04

Supported by

Key Research and Development Project of Hainan Province(ZDYF2019049); Natural Science Foundation of Hainan Province(2019RC198); National Natural Science Foundation of China(21662011); National Natural Science Foundation of China(31660097); National Natural Science Foundation of China(21967008); National Natural Science Foundation of China(32070390); National Natural Science Foundation of China(22067005); Key Research and Development Project of Haikou City(2017050); Key Research and Development Project of Haikou City(20020056)

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Abstract

A new prenylated isoflavone, trigohowine (1), together with seven known isoflavones, was isolated from the stems and leaves of Trigonostemon howii. Their structures were established on the basis of extensive spectral analyses. All known compounds were isolated from the genus Trigonostemon for the first time. The antitumor activities of compounds 1~8were evaluated against five cancer cell lines (HL-60, A549, SMMC-7721, MCF-7 and SW480). The research results showed that compounds 1~8 exhibited obvious inhibitory effects with IC50 values comparable to those of doxorubicin.

Key words： Trigonostemon; Trigonostemon howii; prenylated isoflavone; antitumor activities

Cite this article

Yanhui Fu , Yutong Xie , Qingwei Ma , Bo Jiang , Lan Xie , Zehua Qiao , Yanping Liu . A New Prenylated Isoflavone from the Stems and Leaves of Trigonostemon howii[J]. Chinese Journal of Organic Chemistry, 2021 , 41(3) : 1246 -1250 . DOI: 10.6023/cjoc202008002

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