Chinese Journal of Organic Chemistry >
Recent Progress in the Application of Difluoromethyl Diazomethane as Fluorine-Containing Building Block
Received date: 2020-09-28
Revised date: 2020-11-02
Online published: 2020-12-01
Supported by
National Natural Science Foundation of China(21762054); Outstanding Youth Talent Support Programs from Zunyi Medical University(18ZY-002)
Difluoromethylation has achieved remarkable progress in the past two decades. In addition to the direct difluoromethylation and the stepwise difluoromethylation, chemical transformation starting from CF2H-containing building blocks is a novel strategy to introduce difluoromethyl group into organic compounds. Compared with electrophilic-, nucleo- philic- and free radical-difluoromethylation reagents, the types of CF2H-containing building blocks are still limited and less explored. Among them, difluoromethyl diazomethane (CF2HCHN2) is a new type of fluorine-containing building block developed in recent years, which has received much attention from researchers. The recent progress in the application of difluoromethyl diazomethane and its surrogates as fluorine-containing building blocks is summarized, focusing on the reaction types and related mechanisms, and the developmental direction in the future is prospected.
Wenqing Zhu , Tingyi Xu , Wenyong Han . Recent Progress in the Application of Difluoromethyl Diazomethane as Fluorine-Containing Building Block[J]. Chinese Journal of Organic Chemistry, 2021 , 41(4) : 1275 -1287 . DOI: 10.6023/cjoc202009055
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