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Chinese Journal of Organic Chemistry >

2021 , Vol. 41 >Issue 5: 2127 - 2133

DOI: https://doi.org/10.6023/cjoc202008051

NOTES

A Four-Component Reaction for the Synthesis of Dispirotetrahydro-quinoline-bis(1,3-dioxane-4,6-dione) Derivatives Catalyzed by Tartaric Acid

  • Zhaohui Xu ,
  • Huatao Ye ,
  • Wenfeng Zhang ,
  • Qiang Xiao
Expand
  • a Chemistry and Chemical Engineering Department, Jiangxi Normal University, Nanchang 330022
    b Department of Orthopedics, Jiangxi Province People?s Hospital, Nanchang 330006
* Corresponding authors. E-mail: ;
E-mail:

Received date: 2020-08-27

  Revised date: 2020-12-13

  Online published: 2020-12-31

Supported by

Graduate Innovation Foundation of Jiangxi Province(YC2015-B023); Science and Technology Research Project of Jiangxi Provincial Education Department(GJJ170170); Science and Technology Research Project of Jiangxi Provincial Education Department(GJJ180892); Jiangxi Normal University Doctoral Research Initiation Fund Project(JXSDBY2020-B012)

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Abstract

Eleven dispirotetrahydroquinoline-bis(1,3-dioxane-4,6-dione) derivatives were synthesized by a four-component reaction of 1,3-dioxane-4,6-dione, aromatic aldehydes, arylamines and acetone in the presence of tartaric acid. This method can provide the advantages of high yields, broader substrate scope, mild conditions, simple operation and environmental friendliness. Additionally, the reaction mechanism was also speculated.

Key words： tartaric acid; four-component reaction; 1,3-dioxane-4,6-dione; dispirotetrahydroquinoline-bis(1,3-dioxane-4,6- dione) derivative

Cite this article

Zhaohui Xu , Huatao Ye , Wenfeng Zhang , Qiang Xiao . A Four-Component Reaction for the Synthesis of Dispirotetrahydro-quinoline-bis(1,3-dioxane-4,6-dione) Derivatives Catalyzed by Tartaric Acid[J]. Chinese Journal of Organic Chemistry, 2021 , 41(5) : 2127 -2133 . DOI: 10.6023/cjoc202008051

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