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Chinese Journal of Organic Chemistry >

2021 , Vol. 41 >Issue 4: 1591 - 1598

DOI: https://doi.org/10.6023/cjoc202010046

ARTICLES

Polyketides from the Deep-Sea-Derived FungusDiaporthe phaseolorum FS459

  • Caiyun Hu ,
  • Saini Li ,
  • Yuchan Chen ,
  • Xiaoxia Gao ,
  • Zhaoming Liu ,
  • Weimin Zhang
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  • a State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070
    b College of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006
* Corresponding authors. E-mail: ;
E-mail:

Received date: 2020-10-31

  Revised date: 2020-12-14

  Online published: 2020-12-31

Supported by

National Natural Science Foundation of China(41906106); National Natural Science Foundation of China(31272087); Guangdong Provincial Special Fund for Marine Economic Development Project(GDNRC[2020]042); Guangdong Academy of Sciences Project of Science and Technology Development(2019GDASYL-0103007); Natural Science Foundation of Guangdong Province(2016A030312014)

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Abstract

Ten polyketides, including three new chromone derivatives (1, 2 and 5), a pair of new epimer mixtures (3 and 4), a new azaphilone analogue (6) and four known compounds (7~10) were isolated from the deep-sea-derived fungus Diaporthe phaseolorumFS459. Their structures were elucidated by extensive spectroscopic analysis, while the absolute configurations were established by comparison of experimental and quantum chemical calculated electronic circular dichroism (ECD) spectra. Compounds 1~4 possessed a rare 2?,3?-dimethyl-dioxolane moiety. Thein vitro cytotoxicity, antibacterial activities and NO production inhibitory effects of compounds 1~10 were evaluated.

Key words： polyketides; deep-sea-derived fungus; Diaporthe phaseolorum; cytotoxicity

Cite this article

Caiyun Hu , Saini Li , Yuchan Chen , Xiaoxia Gao , Zhaoming Liu , Weimin Zhang . Polyketides from the Deep-Sea-Derived FungusDiaporthe phaseolorum FS459[J]. Chinese Journal of Organic Chemistry, 2021 , 41(4) : 1591 -1598 . DOI: 10.6023/cjoc202010046

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