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Chinese Journal of Organic Chemistry >

2021 , Vol. 41 >Issue 5: 2029 - 2037

DOI: https://doi.org/10.6023/cjoc202011001

ARTICLES

Study on N-Alkylation Reactions of Trifluoromethylated Acylhydrazones

  • Jinyu Yang ,
  • Danfeng Huang ,
  • Kehu Wang ,
  • Junjiao Wang ,
  • Yingpeng Su ,
  • Zhoubin Deng ,
  • Tianyu Yang ,
  • Yulai Hu
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  • 1 College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070
* Corresponding author. E-mail:

Received date: 2020-11-02

  Revised date: 2020-12-24

  Online published: 2021-02-07

Supported by

National Natural Science Foundation of China(21662030); National Natural Science Foundation of China(22061037)

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Abstract

The N-alkylation reaction of trifluoromethylated acylhydrazones was investigated, and a series of N-alkyl trifluoromethyl acylhydrazones were afforded in good yield. Their structures were confirmed by 1H NMR, 13C NMR and HRMS analysis. The strategy has advantages of simple and mild reaction conditions, wide scope of substrates and good yields. This protocol provides an efficient and new method for the synthesis of N-alkyl substituted trifluoromethyl acylhydrazones.

Key words： trifluoromethyl acylhydrazone; halohydrocarbon; α,β-unsaturated ester; N-alkylation

Cite this article

Jinyu Yang , Danfeng Huang , Kehu Wang , Junjiao Wang , Yingpeng Su , Zhoubin Deng , Tianyu Yang , Yulai Hu . Study on N-Alkylation Reactions of Trifluoromethylated Acylhydrazones[J]. Chinese Journal of Organic Chemistry, 2021 , 41(5) : 2029 -2037 . DOI: 10.6023/cjoc202011001

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