Chinese Journal of Organic Chemistry >
Synthesis and Insecticidal Activity of 3-Ethyl Sulfone Pyridine Substituted Aryl Triazole Compounds
Received date: 2020-09-18
Revised date: 2020-12-14
Online published: 2021-02-22
Supported by
Collaborative Innovation Center of 2011 Green Pesticide(KYY-ZX-20170007)
According to the principle of active substructure splicing, novel 3-ethyl sulfone pyridine substituted aryl triazole compounds were designed and synthesized using 3,6-dichloropyridine-2-carboxylic acid as primary material. All the compounds were characterized by 1H NMR, 13C NMR and HRMS spectra. The preliminary bioassay indicated that most title compounds exhibited relatively high insecticidal activity against Mythimna separata walker at 500 mg/L. Especially 2-(3-(2,6-difluorophenyl)-1-methyl-1H-1,2,4-triazol-5-yl)-3-(ethylsulfonyl)-6-(pyrrolidin-1-yl)pyridine (9c), N-(sec-butyl)-6- (3-(2,6-difluorophenyl)-1-methyl-1H-1,2,4-triazol-5-yl)-5-(ethylsulfonyl)pyridin-2-amine (9g), 6-(3-(2,6-difluorophenyl)-1- methyl-1H-1,2,4-triazol-5-yl)-5-(ethylsulfonyl)-N-isobutylpyridin-2-amine (9h) exhibited mortality 80% against M. separate at 100 mg/L.
Key words： ethylsulfone; triazole; pyridine; synthesis; insecticidal activity
Yangyi Yao , Chaoli Ren , Li Chen , Liangkun Zhong , Tianming Xu , Chengxia Tan . Synthesis and Insecticidal Activity of 3-Ethyl Sulfone Pyridine Substituted Aryl Triazole Compounds[J]. Chinese Journal of Organic Chemistry, 2021 , 41(5) : 2055 -2062 . DOI: 10.6023/cjoc202009042
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