Chinese Journal of Organic Chemistry >
Ligand-Free Iridium-Catalyzed Borylation of Secondary Benzylic C—H Bonds
Received date: 2021-01-05
Revised date: 2021-01-25
Online published: 2021-02-22
Supported by
National Natural Science Foundation of China(21873261)
The ligand-free regioselective iridium-catalyzed C(sp3)—H bond borylation using pyrazole as the directing group is reported. The reaction occurs smoothly at the secondary benzylic position in the presence of a catalytic amount of commercially available [Ir(OMe)(cod)]2. A variety of functionalities could be well tolerated, affording corresponding products in good to excellent yields. The pyrazole could be degraded into amide by ozonolysis.
Key words： C—H activation; iridium; synthetic methods; borylation
Luhua Liu , Rongrong Du , Senmiao Xu . Ligand-Free Iridium-Catalyzed Borylation of Secondary Benzylic C—H Bonds[J]. Chinese Journal of Organic Chemistry, 2021 , 41(4) : 1572 -1581 . DOI: 10.6023/cjoc202101009
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