Chinese Journal of Organic Chemistry >
Studies on the Chemical Synthesis of Natural Drugs Berberine
Received date: 2020-12-31
Revised date: 2021-01-26
Online published: 2021-02-26
Supported by
National Natural Science Foundation of China(21901215); National Natural Science Foundation of China(21672030); Fundamental Research Funds for the Central Universities(2682020CX53); Key Program of Natural Science Foundation of Xinjiang Autonomous Region Colleges(XJEDU2018I018)
Berberine is an important natural drug and a kind of benzyl isoquinoline alkaloid, which has unique four-ring structure. In recent years, pharmacological research has found berberine is expected to be used in the clinical treatment of cancer, diabetes and other frequently occurring diseases. Based on the Woodward’s biosynthetic hypothesis, a schematic review on the synthetic studies towards berberine is provided.
Key words： natural drug; berberine; benzyl isoquinoline; total synthesis
Xifei Yan , Jianfeng Zheng , Wei-Dong Z. Li . Studies on the Chemical Synthesis of Natural Drugs Berberine[J]. Chinese Journal of Organic Chemistry, 2021 , 41(6) : 2217 -2227 . DOI: 10.6023/cjoc202012053
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