Chinese Journal of Organic Chemistry >
Enantioselective Total Synthesis of (–)-Angustureine
Received date: 2021-01-17
Revised date: 2021-02-05
Online published: 2021-02-26
Supported by
National Natural Science Foundation of China-Henan(U1804283); Postgraduate Education Reform and Quality Improvement Project of Henan Province(YJS2021KC03)
(–)-Angustureine is an important member of the tetrahydroquinoline alkaloid family. Such natural products have attracted the attention of synthetic chemists because of their potential biological activities. Starting from methyl (R)-N-Boc- indoline-2-carboxylate, the enantioselective total synthesis of (–)-angustureine was accomplished in 7 steps. The key step of our synthesis involves a rearrangement ring-expansion reaction.
Lulu Yu , Qunshan Ding , Chuanjun Song , Junbiao Chang . Enantioselective Total Synthesis of (–)-Angustureine[J]. Chinese Journal of Organic Chemistry, 2021 , 41(6) : 2507 -2510 . DOI: 10.6023/cjoc202101025
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