Chinese Journal of Organic Chemistry >
Three New Compounds from the Fruits of Forsythia suspensa
Received date: 2020-12-01
Revised date: 2021-01-13
Online published: 2021-03-09
Supported by
National Natural Science Foundation of China(81673313); Drug Innovation Major Project(2018ZX09711001-008)
Three new compounds including two phenylethanoid glycosides derivatives, forsyside A (1) and forsyside B (2), together with a sesquiterpene forsysacid A (3) were isolated from the EtOH extract of the fruits of Forsythia suspensa. Their structures were elucidated from analysis of UV, IR, HRESIMS, and 1D/2D NMR data. The absolute configurations of 1 and 3 were determined by quantum electronic circular dichroism (ECD) calculation, and compound 2 was determined by the ECD exciton chirality method. In addition, all compounds were evaluated for their hepatoprotective activity against N-acetyl-p- aminophenol-induced (APAP) HepG2 cell injury, and compound 2 showed significant activity at a concentration of 10 μmol• L –1.
Xu Zhang , Siyuan Shao , Ziming Feng , Jianshuang Jiang , Ya'nan Yang , Peicheng Zhang . Three New Compounds from the Fruits of Forsythia suspensa[J]. Chinese Journal of Organic Chemistry, 2021 , 41(6) : 2496 -2501 . DOI: 10.6023/cjoc202012003
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