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Chinese Journal of Organic Chemistry >

2021 , Vol. 41 >Issue 7: 2636 - 2649

DOI: https://doi.org/10.6023/cjoc202101041

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Advances on the Total Synthesis of Sesquiterpenoid Alkaloid Dendrobine

  • Jian Xiao ,
  • Yu Peng ,
  • Wei-Dong Z. Li
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  • a Engineering Research Center Biomimetic Synthesis of Natural Drugs of Sichuan Province, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031
    b Key Lab of Natural Product Chemistry and Application in Xinjiang, Yili Normal University, Yining, Xinjiang 835000
* Corresponding author. E-mail:

Received date: 2021-01-25

  Revised date: 2021-02-21

  Online published: 2021-03-12

Supported by

National Natural Science Foundation of China(21772078); Fundamental Research Funds for the Central Universities(2682019CX70); Fundamental Research Funds for the Central Universities(2682019CX71); Fundamental Research Funds for the Central Universities(2682020CX55); Program of Natural Science Foundation of Xinjiang Autonomous Region Colleges (Key Program)(XJEDU2018I018)

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Abstract

Dendrobine is an important sesquiterpenoid alkaloid bearing the picrotoxane carbon skeleton isolated from the traditional Chinese medicine “Chin-Shih-Hu”. Because of structural characteristics of fused polycyclic and seven contiguous stereocenters, and exhibiting analgesic, antipyretic activities, dendrobine has attracted a great deal of attentions from both synthetic organic chemists and medicinal chemists. Over the past 50 years, there has been a number of research reports on the pharmacological activities and chemical synthesis of dendrobine. This review summarizes the biosynthetic hypothesis and synthetic advances on dendrobine.

Key words： natural product; sesquiterpenoid alkaloid; dendrobine; total synthesis; picrotoxane

Cite this article

Jian Xiao , Yu Peng , Wei-Dong Z. Li . Advances on the Total Synthesis of Sesquiterpenoid Alkaloid Dendrobine[J]. Chinese Journal of Organic Chemistry, 2021 , 41(7) : 2636 -2649 . DOI: 10.6023/cjoc202101041

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