Chinese Journal of Organic Chemistry >
One-Pot Three-Component Synthesis of Novel 1,5-Benzodiazepine Derivatives and Their anti-BVDV (Bovine Viral Diarrhea Virus) Activity
Received date: 2020-04-12
Revised date: 2020-06-17
Online published: 2020-09-29
Supported by
the Natural Science Foundation of Hebei Province(B2017209119); the Education Department of Hebei Province(Z2017013)
The “one-pot” three-component reaction is established to synthesize 1,5-benzodiazepine derivatives containing pyrrolidinone. These reactions were carried out readily with p-toluenesulfonic acid (p-TSA) as the catalyst in good yields. Reaction conditions were mild, and environmental friendly. The benzodiazepine derivatives displayed prominent anti-BVDV (bovine viral diarrhea virus) activity with excellent EC50 values and no significant cytotoxicity. Our research could afford significative compounds for the research of anti-BVDV agents.
Chao Han , Lei Nie , Xiao Han , Yan Zhang , Kelei Sun , Lei Shi , Guanghua Cui , Wei Meng . One-Pot Three-Component Synthesis of Novel 1,5-Benzodiazepine Derivatives and Their anti-BVDV (Bovine Viral Diarrhea Virus) Activity[J]. Chinese Journal of Organic Chemistry, 2021 , 41(2) : 819 -825 . DOI: 10.6023/202004018
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