Chinese Journal of Organic Chemistry >
Electrochemistry-Enabled Copper-Catalyzed Oxidation of Benzyl Alcohols for the Preparation of Quinazolinones in Water
Received date: 2020-12-18
Revised date: 2021-03-03
Online published: 2021-03-22
Supported by
Natural Science Foundation of Fujian Province(2015MP008); Natural Science Foundation of Fujian Province(2017J01820); and the Fujian Medical University Sailing Foundation(2018QH2021)
Quinazolinone is one of the most important nitrogen-containing heterocyclic compound, which is widely found in numerous natural products and synthetic drugs. Quinazolinone derivatives were synthesized by one-pot co-oxidation of benzyl alcohol with CuCl2 and electric current in aqueous phase. The reaction provides an efficient protocol to a series of quinazolinones derivatives in good to high yields. This synthesis process features convenient operation and environmental friendliness, which make it a promising method for the preparation of quinazolinone derivatives insteading of expensive and toxic oxidants with electric current.
Key words： electrochemistry; quinazolinone; green chemistry; copper catalysis; water
Mei Wu , Ling Yu , Huiqing Hou , Houzheng Chen , Qinglong Zhuang , Sunying Zhou , Xiaoyan Lin . Electrochemistry-Enabled Copper-Catalyzed Oxidation of Benzyl Alcohols for the Preparation of Quinazolinones in Water[J]. Chinese Journal of Organic Chemistry, 2021 , 41(6) : 2326 -2334 . DOI: 10.6023/cjoc202012028
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