Chinese Journal of Organic Chemistry >
Three New Polyketides from the Culture of Mangrove-Derived FungusEupenicilliumsp. HJ002
Received date: 2021-02-28
Revised date: 2021-03-29
Online published: 2021-04-25
Supported by
Key Research and Development Program of Hainan Province(ZDYF2019183); National Natural Science Foundation of China(31760093); National Natural Science Foundation of Hainan Province(220RC593); National Natural Science Foundation of Hainan Province(218MS045)
A pair of novel isochroman epimers eupenicilchromans A, B, and one new isocoumarin derivative eupenicilmarin A, together with five known compounds were isolated from the culture of mangrove-derived fungusEupenicilium sp. HJ002. The structures of the new compounds, including the absolute configurations, were determined by comprehensive spectroscopic methods, experimental and calculated electronic circular dichroism (ECD) methods. Eupenicilchromans A, B showed potent antioxidant activeties with the IC50 values of 0.6 and 2.6 mmol/L, respectively, and eupenicilchroman A displayed better antioxidant activity than the positive control trolox (IC50=1.6 mmol/L).
Key words： Eupenicillium sp.; isochroman; isocoumarin; antioxidant activity
Jin Cai , Xuhua Nong , Bin Wang , Weinü Zeng , Guolei Huang , Ziyi Zhang , Caijuan Zheng . Three New Polyketides from the Culture of Mangrove-Derived FungusEupenicilliumsp. HJ002[J]. Chinese Journal of Organic Chemistry, 2021 , 41(7) : 2905 -2909 . DOI: 10.6023/cjoc202102052
| [1] | Carroll,A. R.; Copp,B. R.; Davis,R. A.; Keyzers,R. A.; Prinsep,M. R. Nat. Prod. Rep. 2020, 37,175. |
| [2] | Hu,Z. B.; Wu,Z. H.; Su,Q. H.; Li,M. Z.; Wu,S. S.; Meng,R. Q.; Ding,W. J.; Li,C. Y. Bioorg. Chem. 2020, 104,104300. |
| [3] | Liao,H. X.; Shao,T. M.; Mei,R. Q.; Huang,G. L.; Zhou,X. M.; Zheng,C. J.; Wang,C. Y. Mar. Drugs 2019, 17,710. |
| [4] | Yu,X. Q.; Mueller,W. E.G.; Meier, D.; Kalscheuer, R.; Guo,Z. Y.; Zou, K.; Umeokoli,B. O.; Liu, Z.; Proksch, P. Mar. Drugs. 2020, 18,129. |
| [5] | Chen, Y.; Zhang,L. S.; Zou, G.; Li,C. Q.; Yang,W. C.; Liu,H. J.; She,Z. G. Bioorg. Chem. 2020, 97,103712. |
| [6] | Cai,R. L.; Jiang,H. M.; Xiao,Z. E.; Cao,W. H.; Yan, T.; Liu,Z. M.; Lin, S.; Long,Y. H.; She,Z. G. Org. Lett. 2019, 21,9633. |
| [7] | Zheng,C. J.; Bai, M.; Zhou,X. M.; Huang,G. L.; Shao,T. M.; Luo,Y. P.; Niu,Z. G.; Niu,Y. Y.; Chen,G. Y.; Han,C. R. J. Nat. Prod. 2018, 81,1045. |
| [8] | Mei,R. Q.; Nong,X. H.; Wang, B.; Sun,X. P.; Huang,G. L.; Luo,Y. P.; Zheng,C. J.; Chen,G. Y. Nat. Prod. Res. 2020,DOI: 10.1080/14786419.2020.1712388. |
| [9] | Luo,S. L.; Huang,X. J.; Wang, Y.; Jiang,R. W.; Wang, L.; Bai,L. L.; Peng,Q. L.; Song,C. L.; Zhang,D. M.; Ye,W. C. Fitoterapia 2014, 95,115. |
| [10] | Li,X. B.; Li,Y. L.; Zhou,J. C.; Yuan,H. Q.; Wang,X. N.; Lou,H. X. J. Asian Nat. Prod. Res. 2015, 17,182. |
| [11] | Tang,X. X.; Liu,S. Z.; Yan, X.; Tang,B. W.; Fang,M. J.; Wang,X. M.; Wu, Z.; Qiu,Y. K. Mar. Drugs. 2019, 17,509. |
| [12] | Varejao,E. V.V.; Demuner,A. J.; Almeida,L. C.D.; Barreto,R. W. Quim. Nova. 2013, 36,1004. |
| [13] | Xu,Z. Y.; Wu, X.; Li, G.; Feng, Z.; Xu, J. Nat. Prod. Res. 2020, 34,1002. |
| [14] | Cao, F.; Yang, Q.; Shao,C. L.; Kong,C. J.; Zheng,J. J.; Liu,Y. F.; Wang,C. Y. Mar. Drugs 2015, 13,4171. |
| [15] | Zhang, P.; Meng,L. H.; Attila, M.; Li,X. M.; Tibor, K.; Wang,B. G. RSC Adv. 2015, 5,39870. |
| [16] | Chen, Y.; Meng,G. L.; Bai,W. L.; Ma, Y.; Xie,L. P.; Naila, A.; Qian,Y. N.; Han, Y.; Ji, Y. Clin. Exp. Pharmacol. Physiol. 2017, 44,266. |
| [17] | Pierce,C. G.; Uppuluri, P.; Tristan,A. R.; Wormley,F. L.; Mowat, E.; Ramage, G.; Lopez-Ribot,J. L. Nat. Protoc. 2008, 3,1494. |
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