Chinese Journal of Organic Chemistry >
Synthesis of 4(3H)-Quinazolinones by Visible-Light-Induced 2-Benzylaminobenzamides
Received date: 2021-04-21
Revised date: 2021-04-30
Online published: 2021-05-08
Supported by
Science and Technology Commission of Shanghai Municipality(18JC1410801); Medical Engineering Cross Fund of Shanghai Jiao Tong University(YG2019QNA38)
An environmental benign protocol of visible-light-induced reaction has been developed. The methodology allows effective synthesis of 4(3H)-quinazolinones from 2-benzylaminobenzamides in simple and mild reaction conditions. Just irradiation with a blue LED light at room temperature, the reaction proceeds well to provide the corresponding quinazolinones in good to high yields under metal-free, photocatalyst-free and mediator-free conditions. This protocol is demonstrated by its wide substrate scope, good functional group tolerance, operationally simple, and gram-scale reaction. Mechanism studies suggest that a radical pathway might be involved in current reaction.
Key words： visible-light; 2-benzylaminobenzamides; 4(3H)-quinazolinones
Xinchang Li , Huiru Yang , Zheyao Hu , Xin Jin , Wenyi Zhang , Xunxiang Guo . Synthesis of 4(3H)-Quinazolinones by Visible-Light-Induced 2-Benzylaminobenzamides[J]. Chinese Journal of Organic Chemistry, 2021 , 41(8) : 3083 -3088 . DOI: 10.6023/cjoc202104047
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