Chinese Journal of Organic Chemistry >
Palladium-Catalyzed Tandem Heck Cyclization Reactions to Access the Bridged N-Heterocyclic Compounds
Received date: 2021-04-29
Revised date: 2021-05-11
Online published: 2021-05-25
Supported by
National Natural Science Foundation of China(21871240); Fundamental Research Funds for the Central Universities(WK2060000017)
Palladium-catalyzed intramolecular Heck tandem cyclization reactions were developed. With palladium iodide as a catalyst and 4-(dimethylamino)triphenylphosphine as a ligand, 3-substituted indoleamide derivatives were converted to bridged N-heterocyclic products in good yields under simple reaction conditions. The tandem reactions are featured by efficient construction of fused ring compounds in one pot and good functional group compatibility.
Man Li , Ying Wang , Yunhe Xu . Palladium-Catalyzed Tandem Heck Cyclization Reactions to Access the Bridged N-Heterocyclic Compounds[J]. Chinese Journal of Organic Chemistry, 2021 , 41(8) : 3073 -3082 . DOI: 10.6023/cjoc202104059
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