Chinese Journal of Organic Chemistry >
Ammonium Persulfate Promotes Trifluoromethylation of Quinoxalin-2(1H)-ones
Received date: 2020-12-28
Revised date: 2021-04-18
Online published: 2021-06-02
Supported by
Important Science & Technology Specific Projects in Hunan Province(2014FJ1010); Natural Science Fundation of Hunan Province(2018JJ2019)
A green and efficient method for the synthesis of 3-trifluoromethylquinoxalin-2(1H)-ones via direct trifluoromethylation of quinoxalin-2(1H)-ones with CF3SO2Na promoted by ammonium persulfate ((NH4)2S2O8) under mild conditions has been developed. This process is scalable and tolerates a wide spectrum of quinoxalin-2(1H)-one derivatives to deliver corresponding products in good to excellent yields. Comparing to the previous methods, this strategy has the advantages of wide functional groups tolerance, high yield and simple operation, providing an efficient synthetic approach to 3-trifluoromethyl- quinoxalin-2(1H)-ones.
Rongnan Yi , Dongxian Liu , Jiangnan He , Mingming Zhao , Xinhua Xu . Ammonium Persulfate Promotes Trifluoromethylation of Quinoxalin-2(1H)-ones[J]. Chinese Journal of Organic Chemistry, 2021 , 41(8) : 3285 -3291 . DOI: 10.6023/cjoc202012046
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