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Chinese Journal of Organic Chemistry >

2021 , Vol. 41 >Issue 8: 3106 - 3115

DOI: https://doi.org/10.6023/cjoc202102035

ARTICLES

Metal-Free-Involved Cascade Cyclization of Unsaturated Amides with Polychloromethanes

  • Yaxin Ge ,
  • Qinqin Yan ,
  • Yunfei Tian ,
  • Haijun Wang ,
  • Chunfang Zhang ,
  • Zejiang Li
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  • a Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry & Environmental Science, Hebei University, Baoding, Hebei 071002
    b Henan Key Laboratory of Function-Oriented Porous Materia, College of Chemistry and Chemical Engineering, Luoyang Normal University, Luoyang, Henan 471934
*Corresponding authors.E-mail: ;
E-mail: ;
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Received date: 2021-02-20

  Revised date: 2021-04-17

  Online published: 2021-06-02

Supported by

National Natural Science Foundation of China(21702044); National Natural Science Foundation of China(11704024); National Natural Science Foundation of China(21973024); Natural Science Foundation of Hebei Province(B2020201014); Natural Science Foundation of Hebei Province(B2020201006); Science and Technology Project of Hebei Education Department(QN2019063); Key Scientific Research Project of Higher Education of Henan Province(21A150038); Natural Science Foundation of Henan Province(162300410200)

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Abstract

Free radical initiated cascade cyclization of unsaturated amides with polychloromethanes provides a protocol for the selective synthesis of polychlorinated isoquinolinones, or dihydroisoquinolinones. A series of mechanistic studies and optical experiments were operated in this system.

Key words： unsaturated amide; polychloromethane; radical reaction; isoquinolinone; dihydroisoquinolinone

Cite this article

Yaxin Ge , Qinqin Yan , Yunfei Tian , Haijun Wang , Chunfang Zhang , Zejiang Li . Metal-Free-Involved Cascade Cyclization of Unsaturated Amides with Polychloromethanes[J]. Chinese Journal of Organic Chemistry, 2021 , 41(8) : 3106 -3115 . DOI: 10.6023/cjoc202102035

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