Chinese Journal of Organic Chemistry >
Aryl-Iodide-Mediated Electrochemical Aziridination of Electron-Deficient Alkenes
Received date: 2021-05-27
Revised date: 2021-07-06
Online published: 2021-07-20
Supported by
National Natural Science Foundation of China(22071105); National Natural Science Foundation of China(22031008)
A protocol of electrochemical aziridination of electron-deficient alkenes was reported using phthalhydrazide as nitrogen source. The reaction could be conducted in undivided cell, and the ArI is essential to achieve the transformation. Hypervalent-iodine-stablized nitrene and acetyl hydroxyhydrazine were suggested as the in-situ generated nitrogen source for the stepwise aziridination. This protocol can be applied to the azirdination of α,β-unsaturated esters, amides, nitrile and ketones to give a series N-containing molecules.
Feng Liu , Jie Dai , Xu Cheng . Aryl-Iodide-Mediated Electrochemical Aziridination of Electron-Deficient Alkenes[J]. Chinese Journal of Organic Chemistry, 2021 , 41(10) : 4014 -4020 . DOI: 10.6023/cjoc202105046
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