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Chinese Journal of Organic Chemistry >

2021 , Vol. 41 >Issue 11: 4498 - 4503

DOI: https://doi.org/10.6023/cjoc202106025

NOTES

Synthesis, Cyrstal Structure and Fungicidal Activity of New Triazole Compounds Containing Trifluoromethylphenyl Moiety

  • Chensheng Yu ,
  • Han Wang ,
  • Lijing Min ,
  • Liang Han ,
  • Jianjun Shi ,
  • Xinghai Liu
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  • a College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014
    b Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Province, College of Life Science, Huzhou University, Huzhou, Zhejiang 313000
    c College of Chemistry & Chemical Engineering, Huangshan University, Huangshan, Anhui 245041
* Corresponding authors. E-mail:

Received date: 2021-06-11

  Revised date: 2021-07-09

  Online published: 2021-07-26

Supported by

Zhejiang Provincial Natural Science Foundation(LY19C140002); Zhejiang Provincial Natural Science Foundation(LY19B020009); Three Win Material Company(KYY-HX-20200746)

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Abstract

In order to find new lead compounds with high activity, a series of 1,2,4-triazole compounds were designed and synthesized by using Uniconazole as temple compound. Their structures were confirmed by 1H NMR, 13C NMR and HRMS spectra, and the crystal structure of (E)-1-phenyl-2-(1H-1,2,4-triazol-1-yl)-3-(4-(trifluoromethyl)phenyl)allyl-benzoate (5a) was determined by X-ray single crystal diffraction. The bioassay data showed that some of target compounds 5 exhibited good activity (>50%) against Sclerotinia sclerotiorum and Rhizoctonia solanimore at 50 μg/mL.

Key words： synthesis; crystal structure; triazole fungicides; molecular docking

Cite this article

Chensheng Yu , Han Wang , Lijing Min , Liang Han , Jianjun Shi , Xinghai Liu . Synthesis, Cyrstal Structure and Fungicidal Activity of New Triazole Compounds Containing Trifluoromethylphenyl Moiety[J]. Chinese Journal of Organic Chemistry, 2021 , 41(11) : 4498 -4503 . DOI: 10.6023/cjoc202106025

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