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Chinese Journal of Organic Chemistry >

2021 , Vol. 41 >Issue 11: 4504 - 4509

DOI: https://doi.org/10.6023/cjoc202106047

NOTES

New Fusarins from Fusarium graminearum

  • Yueting Lin ,
  • Qian Yang ,
  • Wanqiu Wang ,
  • Qiuju Li ,
  • Zhijun Tang ,
  • Weihua Tang ,
  • Jiang Tao ,
  • Wen Liu
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  • a Department of General Dentistry, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine,College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology, Shanghai 200011
    b State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032
    c CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200032
    d Huzhou Center of Bio-synthetic Innovation, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Huzhou, Zhejiang 313000
† These authors contributed equally to this work.
* Corresponding authors. E-mail: ;

Received date: 2021-06-25

  Revised date: 2021-07-09

  Online published: 2021-07-26

Supported by

National Natural Science Foundation of China(81974495); National Natural Science Foundation of China(32030002); National Natural Science Foundation of China(21977109); National Natural Science Foundation of China(21621002); and the National Key Research and Development Program of China(2018YFA090100); and the National Key Research and Development Program of China(2019YFA0905400)

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Abstract

Fusarins as a group of polyketide-nonribosomal peptide hybrid mycotoxins, are produced by the plant pathogenic fungus Fusarium. The building of core framework depends on an unusual iterative type I polyketide synthase (PKS) fused to a non-ribosomal peptide synthetase (NRPS). Two new compounds, fusarins X1 (1) and Y (2), were isolated from Fusarium graminearum. Fusarin X1 (1) possesses a PKS-NRPS hybrid framework, and fusarin Y (2) is a polyketide. It is demonstrate that they are the main and shunt products in fusarins biosynthetic pathway, respectively, by gene inactivation and HRESIMS analyses. These findings not only lay the foundation for understanding of the fusarins biosynthetic logic, but also provide chemical diversity to further explore the concerning infect mechanism.

Key words： Fusarium graminearum; fusarins; biosynthesis; gene knockout

Cite this article

Yueting Lin , Qian Yang , Wanqiu Wang , Qiuju Li , Zhijun Tang , Weihua Tang , Jiang Tao , Wen Liu . New Fusarins from Fusarium graminearum[J]. Chinese Journal of Organic Chemistry, 2021 , 41(11) : 4504 -4509 . DOI: 10.6023/cjoc202106047

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