Chinese Journal of Organic Chemistry >
Synthesis of Spirobarbiturate Piperidin-2-one Derivatives via Cascade Aza-Michael/Michael Cyclization Reaction
Received date: 2021-05-26
Revised date: 2021-07-02
Online published: 2021-08-09
Supported by
Key Scientific and Technological Project of Henan Province(202102110067); Key Scientific and Technological Project of Henan Province(212102110439); Natural Science Foundation of Henan Province(202300410188); Natural Science Foundation of Henan Province(212300410152); Henan University of Animal Husbandry and Economy(2019HNUAHEDF011); Henan University of Animal Husbandry and Economy(XKYCXJJ2020006)
A highly efficient cascade aza-Michael/intramolecular-Michael reaction employing barbiturate-derived alkenes and N-alkoxy acrylamides has been developed. The reaction proceeds smoothly under mild conditions and is amenable to gram scale synthesis, providing a practical tool in the synthesis of bioactive spirobarbiturate piperidin-2-ones molecules in moderate to good yields.
Key words： spirobarbiturate; piperidin-2-one; cascade reaction; Michael addition
Xuehua Liu , Chuanchuan Wang , Xinlu Wang , Zhiwei Ma , Lei Meng , Degang Ding , Juntao Liu , Yajing Chen . Synthesis of Spirobarbiturate Piperidin-2-one Derivatives via Cascade Aza-Michael/Michael Cyclization Reaction[J]. Chinese Journal of Organic Chemistry, 2021 , 41(11) : 4450 -4458 . DOI: 10.6023/cjoc202105045
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