Chinese Journal of Organic Chemistry >
Recent Advances in Hydrochlorination of Alkenes
Received date: 2021-05-31
Revised date: 2021-07-15
Online published: 2021-08-19
Organochlorides have been widely used in medicine, pesticides, materials and other fields. In addition, organochlorides are also important synthetic building blocks. They have participated in a variety of reactions, such as free radical reactions, substitution reactions and cross-coupling reactions. The hydrochlorination of olefins is one of the most direct and efficient methods for the synthesis of organochlorides, and remakable breakthroughs have been made in the past thirty years. The research progress of olefin hydrochlorination in the past three decades is introduced. According to whether metal catalysis is involved, it is mainly classified into two categories: metal-free alkene hydrochlorination and metal-catalyzed alkene hydrochlorination. Different type of hydrochlorination reactions and related mechanisms are summarized. In addition, the future development direction of alkene hydrochlorination is prospected.
Key words： alkene; hydrochlorination; hydrogen chloride; organochloride; metal catalysis
Yaoxin Wang , Chen Cui , Xiaohui Yang . Recent Advances in Hydrochlorination of Alkenes[J]. Chinese Journal of Organic Chemistry, 2021 , 41(10) : 3808 -3815 . DOI: 10.6023/cjoc202105057
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