Chinese Journal of Organic Chemistry >
Recent Advances in Electrochemical C(3)—H Functionalization of Quinoxalin-2(1H)-ones
Received date: 2021-07-18
Revised date: 2021-09-04
Online published: 2021-09-15
Supported by
National Natural Science Foundation of China(21901219); Key Project of Education Department of Henan Province(20B150024); Young Key Teacher Training Plan of Henan Provincial Higher Education in 2021(2021GGJS146); Open Subject Research Fund of the Key Laboratory of Drug Quality Control and Evaluation in Henan Province and the Young Backbone Teachers Project of Xuchang University
Quinoxalinone and its derivatives are a class of important nitrogen heterocyclic compounds, which widely exist in natural products, drugs and functional materials. Therefore, the C—H functionalization of quinoxalinone has attracted extensive attention of chemical workers. In recent years, electrochemical synthesis directly uses electron as a “clean reagent” to participate in redox reaction without additional redox reagent, which has the characteristics of mild reaction conditions and good atom economy. This method meets the requirements of green chemistry and sustainable development. With the in-depth study on the mechanism of electrochemical synthesis and the standardization of reaction equipment, this method has become a powerful tool for functionalization of quinoxalineones. The recent advances in the electrochemical C(3)—H functionalization of quinoxaline-2(1H)-one are summarized. The reaction transformation conditions and mechanisms are systematically discussed, and the challenges and future directions of this field are included.
Dandan Li , Xiaochen Wang , Shanshan Li , Chenyu Fu , Qianqian Li , Dongtao Xu , Yingying Ma . Recent Advances in Electrochemical C(3)—H Functionalization of Quinoxalin-2(1H)-ones[J]. Chinese Journal of Organic Chemistry, 2021 , 41(12) : 4610 -4622 . DOI: 10.6023/cjoc202107042
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