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Chinese Journal of Organic Chemistry >

2021 , Vol. 41 >Issue 12: 4696 - 4703

DOI: https://doi.org/10.6023/cjoc202112016

ARTICLES

Electrochemical Annulations of o-Alkynylanilines for Synthesis of 3-Iodoindoles

  • Hehua Xu ,
  • Xiangtai Meng ,
  • Yu Zheng ,
  • Jinyue Luo ,
  • Shenlin Huang
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  • a Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037
    b International Innovation Center for Forest Chemicals and Materials, Nanjing 210037
* Corresponding authors. E-mail: ;

Received date: 2021-12-08

  Revised date: 2021-12-19

  Online published: 2021-12-22

Supported by

National Natural Science Foundation of China(32171724)

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Abstract

Indole, as one of the most important nitrogen-containing heterocyclic compound, is found widely in various natural products and synthetic drugs. 3-Iodoindoles play an important role as intermediate in the selective functionalization of indoles. 3-iodoindoles could be conveniently synthesized by electrochemical annulations of o-alkynylanilines with readily available iodide salt. This sustainable electrolysis strategy provides an efficient access to a series of 3-iodoindoles in good to excellent yields under external oxidant-free, base-free conditions and features broad functional group tolerance.

Key words： electrosynthesis; annulation; 3-iodoindoles; o-alkynylanilines

Cite this article

Hehua Xu , Xiangtai Meng , Yu Zheng , Jinyue Luo , Shenlin Huang . Electrochemical Annulations of o-Alkynylanilines for Synthesis of 3-Iodoindoles[J]. Chinese Journal of Organic Chemistry, 2021 , 41(12) : 4696 -4703 . DOI: 10.6023/cjoc202112016

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