Chinese Journal of Organic Chemistry >
I2-Catalyzed Cyclization of β-Ketonitrile with 1H-Pyrazol-5-amine
Received date: 2022-06-12
Revised date: 2022-08-16
Online published: 2022-09-15
Supported by
National Natural Science Foundation of China(21563025); National Natural Science Foundation of China(22162022)
An I2-catalyzed cyclization reaction of 1H-pyrazol-5-amine and β-ketonitrile for the synthesis of pyrazolo[1,5- a]pyrimidines was developed. This method provides an efficient way to obtain structurally diverse pyrazolo[1,5-a]pyrimidine derivatives in good to excellent yields. The method has the advantages of simple operation, mild reaction conditions and a wide range of substrates. It can also be scaled up.
Key words： I2-catalyzed; cyclization reaction; pyrazolo[1,5-a]pyrimidines
Tian Sang , Fan Jia , Jing He , Chuntian Li , Yan Liu , Ping Liu . I2-Catalyzed Cyclization of β-Ketonitrile with 1H-Pyrazol-5-amine[J]. Chinese Journal of Organic Chemistry, 2023 , 43(1) : 195 -201 . DOI: 10.6023/cjoc202206017
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