Chinese Journal of Organic Chemistry >
A New Prenylated Isoflavone from the Stems of Harrisonia perforata
Received date: 2022-07-04
Revised date: 2022-08-09
Online published: 2022-10-10
Supported by
Key Research and Development Project of Hainan Province(ZDYF2022SHFZ028); National Natural Science Foundation of China(22067005); National Natural Science Foundation of China(32070390); National Natural Science Foundation of China(21967008); National Natural Science Foundation of Hainan Province(222RC655); National Natural Science Foundation of Hainan Province(2019RC198); National Natural Science Foundation of Hainan Province(220RC596); Key Research and Development Project of Haikou City(2017050); Key Research and Development Project of Haikou City(2020054)
A new prenylated isoflavone, harriperforine (1), as well as seven known analogues, was isolated and characterized from the stems of Harrisonia perforata. Their chemical structures were unambiguously elucidated based on spectroscopic analyses. All known compounds 2~8 were isolated from the genus Harrisonia for the first time. The growth inhibitory activities against five cancer cell lines (HL-60, A549, SMMC-7721, MCF-7 and SW480) of compounds 1~8 were evaluated. As a result, compounds 1~8 displayed remarkable inhibitory activities with IC50 values ranging from (0.38±0.03) μmol/L to (31.68±0.21) μmol/L, which were comparable to those of cisplatin.
Zhangyang Shen , Yujie Li , Yimeng Zhao , Yayuan Deng , Yawen Guo , Yu Wang , Yanping Liu , Yanhui Fu . A New Prenylated Isoflavone from the Stems of Harrisonia perforata[J]. Chinese Journal of Organic Chemistry, 2023 , 43(2) : 771 -776 . DOI: 10.6023/cjoc202207005
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