Chinese Journal of Organic Chemistry >
Progress in the Study of α-Functionalization of Enaminone
Received date: 2022-07-18
Revised date: 2022-08-26
Online published: 2022-10-14
Supported by
Scientific and Technological Project of Henan Province(222102310580)
Enaminones are versatile and extremely useful building blocks in organic synthesis with the advantages of easy availability, convenient storage, and distinct reactivity. In particular, such compounds are important precursors in heterocyclic chemistry. Recently, transition-metal-catalyzed or transition-metal-free α-functionalization of enaminones by C-H activation has emerged as a more atom- and step-economical strategy for the construction of functionalized enaminones or various heterocycles, and it has attracted the attention of many organic chemists. This review is divided into five sections based on the varied chemical bonds: C-C bond formation, C-O bond formation, C-N bond formation, C-X bond formation, and C-S/Se bond formation. The recent progress in functionalization of enaminone based on the reaction mechanism, reaction system, the scope of substrates, etc. is systematically reviewed.
Key words： enaminone; functionalization; coupling reaction; hypervalent iodine
Ning Liu , Xiaodan Cuan , Hui Li , Xiyan Duan . Progress in the Study of α-Functionalization of Enaminone[J]. Chinese Journal of Organic Chemistry, 2023 , 43(2) : 602 -621 . DOI: 10.6023/cjoc202207027
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