Chinese Journal of Organic Chemistry >
Synthesis of p-Alkoxy Phenol and Its Application after Dearomatization
Received date: 2022-09-11
Revised date: 2022-11-09
Online published: 2022-12-14
Supported by
Project from University Discipline Innovation and Talent Introduction Base of Science and Technology Department of Henan Province(HNGD2021047); Key Scientific Research Project of Henan Provincial Department of Education(21A350008)
p-Alkoxy phenol (p-AOPs) compounds were obtained by one-step selective hydroxylation of alkoxyl-aryl ethers with the transition metal ruthenium(II) as catalyst and [bis(trifluoroacetoxy)iodo]benzene (PIFA) as oxidant. These p-AOPs could be easily converted to quinone monoacetals (QMAs) after dearomatization. Condensation of the QMAs with β-naphthols provided polycyclic benzofurans which have a wide application prospect. The protocol established in this paper offered a facile and reliable way for the synthesis of these important compounds.
Xiaojing Hu , Feixiang Guo , Runqing Zhu , Bingqi Zhou , Tao Zhang , Lizhen Fang . Synthesis of p-Alkoxy Phenol and Its Application after Dearomatization[J]. Chinese Journal of Organic Chemistry, 2023 , 43(6) : 2239 -2244 . DOI: 10.6023/cjoc202209012
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