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Chinese Journal of Organic Chemistry >

2023 , Vol. 43 >Issue 3: 1157 - 1167

DOI: https://doi.org/10.6023/cjoc202210009

ARTICLES

Photocatalyzed 2∶2 Coupling of Styrene and BrCF2CO2Me: A Facile Synthesis of Bis-difluoroacetylated Hexestrol Derivatives

  • Shenhao Chen ,
  • Song Zou ,
  • Chanjuan Xi
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  • a Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084
    b State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071
* Corresponding author. E-mail:

Received date: 2022-10-10

  Revised date: 2022-11-17

  Online published: 2022-12-14

Supported by

National Natural Science Foundation of China(21871163); National Natural Science Foundation of China(22071134); National Natural Science Foundation of China(21911530097)

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Abstract

Photoredox-catalyzed 2∶2 coupling of styrene and BrCF2CO2Me is reported, which undergoes a homo-coupling of in situ generated β-CF2CO2Me substituted benzyl radical. The reaction features a wide substrate scope and functional group tolerance to afford bis-difluoroacetylated hexestrol derivatives with high yields.

Key words： photocatalysis; radical homo-coupling; hexestrol derivatives

Cite this article

Shenhao Chen , Song Zou , Chanjuan Xi . Photocatalyzed 2∶2 Coupling of Styrene and BrCF2CO2Me: A Facile Synthesis of Bis-difluoroacetylated Hexestrol Derivatives[J]. Chinese Journal of Organic Chemistry, 2023 , 43(3) : 1157 -1167 . DOI: 10.6023/cjoc202210009

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