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Chinese Journal of Organic Chemistry >

2023 , Vol. 43 >Issue 6: 2245 - 2251

DOI: https://doi.org/10.6023/cjoc202211014

Three New C19-Diterpenoid Alkaloids from Aconitum brevicalcaratum

  • Feng Xing ,
  • Hao Zeng ,
  • Qian Li ,
  • Dan Wan ,
  • Huanhuan Ding ,
  • Jiang Xie ,
  • Lin Chen ,
  • Xianli Zhou
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  • a School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031
    b Key laboratory of Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu 610031
    c Affiliated Hospital of Southwest Jiaotong University ＆ The Third People Hospital of Chengdu, Chengdu 610031
* E-mail: ;

Received date: 2022-11-10

  Revised date: 2022-12-21

  Online published: 2023-01-12

Supported by

National Natural Foundation of China(82073734); Science and Technology Support Programs of Sichuan Province(2021YJ0222); Research Foundation for Administration of Traditional Chinese Medicine of Sichuan Province(2020HJZX002); Fundamental Research Funds for Central Universities(2682021CX085); College Students' Innovative Entrepreneurial Training Plan Program(202210613076)

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Abstract

Three new C19-diterpenoid alkaloids, brevicalcarines A~C (1~3), together with seven known compounds (4~10), were isolated from the roots of A. brevicalcaratum (Finet et Gagnep.) Diels. Their structures were determined by HR-ESI-MS (high resolution electrospray ionization mass spectroscopy), IR (Infrared absorption spectroscopy), 1D NMR (One-dimensional nuclear magnetic resonance), 2D NMR (Two-dimensional nuclear magnetic resonance) and X-ray crystallographic analysis. Brevicalcarine A (1) was a new diterpenoid alkaloid with vaginatunine A fragment at C-18, while brevicalcarine B (2) and brevicalcarine C (3) were new C19-diterpenoid alkaloid with an acetoxy group at C-18. In addition, the anti-neuroinflammatory activity of these compounds against BV-2 cells was investigated, which showed that none of them had significant anti-neuroinflammatory activity.

Key words： ranunculaceae; Aconitum brevicalcaratum; diterpenoid alkaloid; anti-neuroinflammatory activity

Cite this article

Feng Xing , Hao Zeng , Qian Li , Dan Wan , Huanhuan Ding , Jiang Xie , Lin Chen , Xianli Zhou . Three New C19-Diterpenoid Alkaloids from Aconitum brevicalcaratum[J]. Chinese Journal of Organic Chemistry, 2023 , 43(6) : 2245 -2251 . DOI: 10.6023/cjoc202211014

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