Chinese Journal of Organic Chemistry >
Visible Light-Catalyzed Synthesis of Difluoroalkylated Polycyclic Indoles
Received date: 2022-12-26
Revised date: 2023-02-17
Online published: 2023-02-23
Supported by
National Natural Science Foundation of China(21871049)
Polycyclic indoles are widely found in natural products and pharmaceutical molecules, and have a wide range of applications in the pharmaceutical, pesticide and dye industries. Although considerable development has been made in the synthesis of indole polycycles, it is still of great scientific interest and value to explore more efficient and milder experimental strategies for the synthesis of highly-functionalized polycyclic indoles. Herein, a one-step radical tandem cyclization reaction to synthesize difluoroalkylindoles with quaternary carbon centers by using difluorobromoesters as the fluorine source and 3-alkenyl indoles as the substrates under visible light-catalyzed conditions was developed. The method is easy-to-operate and mild in conditions, with a wide range of substrate adaptability and good yields, providing a green and efficient synthetic route for fluorine-containing polycyclic indoles.
Jinxiao Zhao , Tonghui Wei , Sen Ke , Yi Li . Visible Light-Catalyzed Synthesis of Difluoroalkylated Polycyclic Indoles[J]. Chinese Journal of Organic Chemistry, 2023 , 43(3) : 1102 -1114 . DOI: 10.6023/cjoc202212032
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