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Chinese Journal of Organic Chemistry >

2023 , Vol. 43 >Issue 2: 411 - 425

DOI: https://doi.org/10.6023/cjoc202210016

Recent Progress in Selective C-F Bond Activation of Trifluoromethyl Alkenes

  • Shuyong Song ,
  • Senmiao Xu
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  • a State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000
    b University of Chinese Academy of Sciences, Beijing 100049
* Corresponding author. E-mail:

Received date: 2022-10-17

  Revised date: 2022-11-03

  Online published: 2022-11-04

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Abstract

Selective C-F bond activation of the trifluoromethyl group is an important approach for the synthesis of gem-difluoro compounds. Given the importance of trifluoromethyl alkenes in synthetic chemistry as well as their diversity in selectivity, the research on selective C-F bond activation of these compounds has received considerable interest. To this end, The research progress is summarized, including nucleophilic addition/defluorination (SN2' type), acid-promoted defluorinative Friedel-Crafts arylation, (formal) ipso-defluorinative functionalization, and transition-metal-catalyzed migratory insertion/ defluorination.

Key words： trifluoromethyl alkene; C-F bond activation; synthetic method

Cite this article

Shuyong Song , Senmiao Xu . Recent Progress in Selective C-F Bond Activation of Trifluoromethyl Alkenes[J]. Chinese Journal of Organic Chemistry, 2023 , 43(2) : 411 -425 . DOI: 10.6023/cjoc202210016

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