Chinese Journal of Organic Chemistry >
Research Progress of Amino Acids as Transient Directing Groups in C—H Bond Activation Reactions
Received date: 2022-12-09
Revised date: 2023-02-03
Online published: 2023-03-07
Supported by
National Natural Science Foundation of China(21978067); Natural Science Foundation of Hebei Province(H2020208030); the Open Funding Project of the Hebei Province Key Laboratory of Molecular Chemistry for Drug(2022PT03)
In recent years, the transient directing group (TDG)-based strategy of C—H activation has attracted significant attention. Compared with the typical C—H activation reactions, TDG-assisted C—H activation does not require external pre-installation and post-removal steps of directing groups, which significantly improve the atom and step economy. Amino acid-based TDGs for C—H activation have achieved significant successes among the known TDGs. Amino acids have the advantages including low cost, widely existing and diverse structures. The site selectivity of C—H activation can be controlled by using α- or β-amino acids. By using the inherent chirality of amino acids, the stereo-selectivity of reactions can be realized. The research progress of transition-metal-catalyzed C—H bond activation and functionalization with amino acids as TDGs in recent years is summarized, which is classified according to the type of amino acids for C—H activation reactions of various substrates. Finally, the limitations of previous works and perspectives on this cutting-edge area are also described.
Key words： transient directing group; amino acid; C—H activation; transition metal
Sifan Dong , Haolong Li , Yuan Qin , Shiming Fan , Shouxin Liu . Research Progress of Amino Acids as Transient Directing Groups in C—H Bond Activation Reactions[J]. Chinese Journal of Organic Chemistry, 2023 , 43(7) : 2351 -2367 . DOI: 10.6023/cjoc202212012
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