Chinese Journal of Organic Chemistry >
Two New Labdane Diterpenoids from the Leaves of Callicarpa nudiflora
Received date: 2020-12-15
Revised date: 2023-01-29
Online published: 2023-03-07
Supported by
Key R&D Projects in Hainan Province-Social Development(ZDYF2022SHFZ286); Key R&D Projects in Hainan Province-Social Development(ZDYF2021SHFZ072); Hainan Provincial Natural Science Foundation(221MS034); Education Department of Hainan Province(Hnky2021-30); National Natural Science Foundation of China(21662012); Innovation Platform for Academicians of Hainan Province(YSPTZX202030); Central Government Guides Local Science and Technology Development(ZY2022HN08)
Two new labdane diterpenoids 3-oxo-7-hydroxy-8(17),13E-labdadien-15-oic acid (1), 3-oxo-8-hydroxy-13E-lab- den-15-oic acid (2), and five known terpenoids were obtained from the leaves of Callicarpa nudiflora during a systematic phytochemical investigation. The structures were elucidated using comprehensive spectroscopic methods [nuclear magnetic resonance spectroscopy (NMR) and high resolution electrospray ionization mass spectroscopy (HR-ESI-MS)], and the absolute configuration of 1 was established based on single-crystal X-ray diffraction. The inhibitory activity of all the compounds on NO production in lipopolysaccharide-induced (LPS) mouse leukemia cells of monocyte macrophage (RAW 264.7) cells was evaluated. Compounds 1 and 2 showed potential anti-inflammatory activity with IC50 values of (10.3±0.3) and (12.7±0.4) μmol/L, respectively.
Key words： C. nudiflora; labdane diterpenes; sesquiterpenes
Zhangxin Yu , Yuqin Meng , Menglin Xue , Xiaobao Li , Guangying Chen , Changri Han . Two New Labdane Diterpenoids from the Leaves of Callicarpa nudiflora[J]. Chinese Journal of Organic Chemistry, 2023 , 43(7) : 2567 -2571 . DOI: 10.6023/cjoc202212020
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