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Chinese Journal of Organic Chemistry >

2023 , Vol. 43 >Issue 8: 2913 - 2925

DOI: https://doi.org/10.6023/cjoc202303004

Visible-Light-Induced Difluoroalkylated Cyclization of Novel Functionalized Aromatic Isocyanides

  • Yingke Feng ,
  • He Wang ,
  • Mengxing Cui ,
  • Ran Sun ,
  • Xin Wang ,
  • Yang Chen ,
  • Lei Li
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  • School of Petrochemical Engineering, Liaoning Petrochemical University, Fushun, Liaoning 113001
*E-mail: ;

Received date: 2023-03-01

  Revised date: 2023-04-03

  Online published: 2023-04-10

Supported by

The National Natural Science Foundation of China(21702087); The National Natural Science Foundation of China(21801105); The Liaoning Revitalization Talents Program(XLYC1907010); The Natural Science Foundation of Liaoning Province(2022MS361); The Natural Science Foundation of Liaoning Province(2021BS249); The Research Project Fund of Liaoning Provincial Department of Education(LJKZ0373); The Research Project Fund of Liaoning Provincial Department of Education(LJKZ0375)

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Abstract

In this study, a visible-light photoredox-catalyzed difluoroalkylation of newly designed functionalized aromatic isocyanides with commercially available CF2 precursors was reported. A series of CF2-containing indole-1,2-fused diazepanones were constructed in cascade reaction through a sequence of radical addition/cyclization processes under mild conditions. This reaction not only generated a class of polycyclic indole fused seven-membered nitrogen heterocycles but also expanded the reactions of functionalized isocyanides.

Key words： functionalized aromatic isocyanides; radical cyclization; difluoroalkylation; indole fused seven-membered nitrogen heterocycles

Cite this article

Yingke Feng , He Wang , Mengxing Cui , Ran Sun , Xin Wang , Yang Chen , Lei Li . Visible-Light-Induced Difluoroalkylated Cyclization of Novel Functionalized Aromatic Isocyanides[J]. Chinese Journal of Organic Chemistry, 2023 , 43(8) : 2913 -2925 . DOI: 10.6023/cjoc202303004

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