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Chinese Journal of Organic Chemistry >

2023 , Vol. 43 >Issue 8: 2878 - 2884

DOI: https://doi.org/10.6023/cjoc202301003

A Highly Selective Ratiometric Fluorescent Probe for the Detection of Hypochlorite in Acute Lung Injury

  • Binghui Ding ,
  • Shaohui Han ,
  • Haiqing Xiong ,
  • Benhua Wang ,
  • Bojun Zuo ,
  • Xiangzhi Song
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  • a College of Chemistry & Chemical Engineering, Central South University, Changsha 410083
    b Shandong Academy of Pesticide Sciences, Jinan 250033
*E-mail: ;

Received date: 2023-01-04

  Revised date: 2023-03-12

  Online published: 2023-04-14

Supported by

The National Natural Science Foundation of China(22178395)

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Abstract

The fluorescent probe for the detection of overexpressed ClO－ in acute lung injury is required to have high selectivity against other reactive species. A hydroxybenzo[g]coumarin, NaphCou, was synthesized as a ratiometric fluorescent probe to detect ClO－ with ultra-high selectivity, a fast response, long-wavelength emissions (from green to red) and large Stokes shifts (from 107 nm to 155 nm). Using probe NaphCou as a fluorescence sensing tool, the lipopolysaccharide (LPS)-induced acute lung injury in mouse model was investigated by monitoring the hypochlorous acid concentration variation.

Key words： acute lung injury; hypochlorous acid; fluorescent probe; ratiometric measurement

Cite this article

Binghui Ding , Shaohui Han , Haiqing Xiong , Benhua Wang , Bojun Zuo , Xiangzhi Song . A Highly Selective Ratiometric Fluorescent Probe for the Detection of Hypochlorite in Acute Lung Injury[J]. Chinese Journal of Organic Chemistry, 2023 , 43(8) : 2878 -2884 . DOI: 10.6023/cjoc202301003

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