Chinese Journal of Organic Chemistry >
Progress in the Syntheses of α-Boryl Carbonyl Compounds
Received date: 2023-03-17
Revised date: 2023-04-14
Online published: 2023-04-26
Supported by
National Natural Science Foundation of China(22022114); National Natural Science Foundation of China(21971261); Guangdong Basic and Applied Basic Research Foun- dation(2020A1515010624); Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program(2017BT01Y093)
α-Boryl carbonyl compounds have traditionally been considered thermodynamically unstable and prone to undergo 1,3-boron migration. In recent years, with the development and understanding of sp3-hybridized boron or tetra-coordinated boron, methods for synthesizing stable and separable α-boryl carbonyl compounds have been actively developed. These methods include the insertion reaction of borane with diazo esters, sulfur ylides and other carbene precursors, the free-radical borylation reaction of α,β-unsaturated carbonyl compounds, and late-stage structural modification reactions of boron-contain- ing compounds. The recent advances in the synthesis of α-boryl carbonyl compounds are reviewed based on different reaction types, and the existing challenges and future research directions are discussed.
Zhihao Chen , Qi Fan , Biaolin Yin , Qingjiang Li , Honggen Wang . Progress in the Syntheses of α-Boryl Carbonyl Compounds[J]. Chinese Journal of Organic Chemistry, 2023 , 43(5) : 1706 -1712 . DOI: 10.6023/cjoc202303025
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