Chinese Journal of Organic Chemistry >
Recent Progress on [3+2] Ring-Expansion Reaction of Aziridines with Unsaturated Compounds
Received date: 2023-05-09
Revised date: 2023-07-11
Online published: 2023-08-30
Supported by
National Natural Science Foundation of China(22171036); National Natural Science Foundation of China(22007028); Natural Science Foundation of Henan Province(232300421126); Open Research Fund of School of Chemistry and Chemical Engineering, Henan Normal University(2020YB03)
Due to their high ring strain, aziridines readily undergo ring-expansion reactions, reacting with various unsaturated compounds to form heterocyclic compounds. These heterocyclic compounds serve as important scaffolds for drugs, natural products, and bioactive molecules. Additionally, they are valuable organic intermediates with wide-ranging applications in medicine, agriculture, chemical engineering, organic synthesis, and related fields. In recent years, there has been a significant increase in the synthesis of heterocyclic compounds using aziridines as three-atom synthons, resulting in a rapid advancement of research in this area. This review aims to provide an overview of the most recent [3+2] ring-expansion reactions involving aziridines and unsaturated compounds, such as olefins, aldehydes, ketones, and nitriles, over the past decade. Furthermore, the prospect in this field is also discussed.
Key words： aziridine; heterocyclic compound; [3+2] ring-expansion reaction
Erjun Hao , Xiaobo Ding , Kexin Wang , Honghao Zhou , Qiliang Yang , Lei Shi . Recent Progress on [3+2] Ring-Expansion Reaction of Aziridines with Unsaturated Compounds[J]. Chinese Journal of Organic Chemistry, 2023 , 43(12) : 4057 -4074 . DOI: 10.6023/cjoc202305008
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