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Chinese Journal of Organic Chemistry >

2023 , Vol. 43 >Issue 12: 4213 - 4219

DOI: https://doi.org/10.6023/cjoc202307026

ARTICLES

Visible-Light Induced Organophotocatalysis for the Synthesis of Difluoroethylated Benzoxazines

  • Xiang Chen ,
  • Wen-Tao Ouyang ,
  • Xiao Li ,
  • Wei-Min He
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  • School of Chemistry and Chemical Engineering, University of South China, Hengyang, Hunan 421001
*

Received date: 2023-07-28

  Revised date: 2023-09-04

  Online published: 2023-09-15

Supported by

Natural Science Foundation of Hunan Province(2023JJ40528)

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Abstract

Benzoxazines are important motif in pharmaceuticals and functional molecules. A visible-light induced photocatalytic strategy for the synthesis of difluoroethyl benzoxazines with organo-photocatalyst was developed. In the present protocol, a series of olefinic amides can be transferred to difluoroethylated benzoxazines via oxydifluoromethylation with CF2HSO2Na as difluoromethylating reagent, which is easily operated and good functional group tolerant.

Key words： oxydifluoromethylation; benzoxazine; visible light induced reaction; organophotocalyst; radical

Cite this article

Xiang Chen , Wen-Tao Ouyang , Xiao Li , Wei-Min He . Visible-Light Induced Organophotocatalysis for the Synthesis of Difluoroethylated Benzoxazines[J]. Chinese Journal of Organic Chemistry, 2023 , 43(12) : 4213 -4219 . DOI: 10.6023/cjoc202307026

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